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Correlations between gray matter reductions and cognitive deficits in dementia with Lewy Bodies and Parkinson's disease with dementia

✍ Scribed by Cristina Sanchez-Castaneda; Ramon Rene; Blanca Ramirez-Ruiz; Jaume Campdelacreu; Jordi Gascon; Carles Falcon; Matilde Calopa; Serge Jauma; Montserrat Juncadella; Carme Junque

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 145 KB
Volume: 24
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.22488

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✦ Synopsis

Abstract

There is controversy regarding whether Dementia with Lewy Bodies (DLB) and Parkinson's disease with dementia (PDD) may or not be different manifestations of the same disorder. The purpose of the present study was to investigate possible correlations between brain structure and neuropsychological functions in clinically diagnosed patients with DLB and PDD. The study sample consisted of 12 consecutively referred DLB patients, 16 PDD patients, and 16 healthy control subjects recruited from an outpatient setting, who underwent MRI and neuropsychological assessment. Voxel‐based morphometry results showed that DLB patients had greater gray matter atrophy in the right superior frontal gyrus, the right premotor area and the right inferior frontal lobe compared to PDD. Furthermore, the anterior cingulate and prefrontal volume correlated with performance on the Continuous Performance Test while the right hippocampus and amygdala volume correlated with Visual Memory Test in the DLB group. In conclusion, DLB patients had more fronto‐temporal gray matter atrophy than PDD patients and these reductions correlated with neuropsychological impairment. © 2009 Movement Disorder Society

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