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Correlation of WT1 expression with the burden of total and residual leukemic blasts in bone marrow samples of acute myeloid leukemia patients

✍ Scribed by Juan Manuel Alonso-Dominguez; Maria Tenorio; Diego Velasco; Lorena Abalo; Sara Lozano; Jesus Villarrubia; Javier López-Jimenez; Silvia Grande; Rosa Ayala


Book ID
116332675
Publisher
Elsevier
Year
2012
Tongue
English
Weight
75 KB
Volume
205
Category
Article
ISSN
2210-7762

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Both WT1 and PRAME are highly expressed in acute myeloid leukemia (AML) patients. To assess the efficacy of their simultaneous detection for the purpose of monitoring minimal residual disease (MRD), we used real-time quantitative RT-PCR to quantify both WT1 and PRAME transcript levels in the bone ma