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Correlation of tumor markers p53, bcl-2 and cathepsin-D with clinicopathologic features and disease-free survival in laryngeal squamous cell carcinoma

✍ Scribed by Andreas Ch. Lazaris; Irene Lendari; Nikolaos Kavantzas; Dimitrios Kandiloros; Georgios Adamopoulos; Panagiotis Davaris

Book ID: 114431015
Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 647 KB
Volume: 50
Category: Article
ISSN: 1320-5463
DOI: 10.1046/j.1440-1827.2000.01110.x

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## Abstract ## Background. The p53 protein, a well‐known tumor suppressor that functions primarily as a transcription factor, initiates cell cycle arrest and apoptosis after genotoxic stress. The antiapoptotic regulator Bcl‐2 is a downstream modulator of p53‐induced apoptosis. Loss of function of