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Correlation of transformation from epithelial to mesenchymal-like morphology and endogenous bFGF levels in human nasopharyngeal carcinoma cells

✍ Scribed by Jan-Kan Chen; Ling-Shang Shen; Hsiou-Hsian Chao


Book ID
102885167
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
883 KB
Volume
160
Category
Article
ISSN
0021-9541

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✦ Synopsis


CG-1 human nasopharyngeal carcinoma cells in monolayer culture formed both cohesive, epithelial-like colonies and scattered, fibroblastic-like colonies in mixed proportions. In the presence of exogenously added bFGF (4 nglml), about 85% of the colonies formed were fibroblastic-like. CC-1 cells were capable of synthesizing and releasing bFGF, and, when compared by the immunological