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Correlation of structural elements and infectivity of the HET-s prion

✍ Scribed by Ritter, Christiane; Maddelein, Marie-Lise; Siemer, Ansgar B.; Lührs, Thorsten; Ernst, Matthias; Meier, Beat H.; Saupe, Sven J.; Riek, Roland

Book ID
109894401
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
936 KB
Volume
435
Category
Article
ISSN
0028-0836

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Chem. 72, 211}222) proposed a model for the dynamics of diseases of the central nervous system caused by prions. It is based on the protein-only hypothesis (Prusiner et al., 1981, Proc. Natl. Acad. Sci. ;.S.A. 78, 6675}6679), which assumes that infection can be spread by particular proteins (prions)