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Correlation of Promoter Methylation in the MGMT Gene with Glioma Risk and Prognosis: a Meta-Analysis

โœ Scribed by Dong, Xiang; Liu, Rong-Yao; Chen, Wei-Dong

Book ID
125377613
Publisher
Springer
Year
2015
Tongue
English
Weight
369 KB
Volume
52
Category
Article
ISSN
0893-7648

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The enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) protects cells from the cytotoxic and mutagenic effects of alkylating agents. Approximately 20% of tumor cell lines lack MGMT activity and are highly sensitive to alkylating agents. In established cancer cell lines, MGMT expression appears t