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Correlation of Parkinson's disease severity and duration with 123I-FP-CIT SPECT striatal uptake

✍ Scribed by Hani T. S. Benamer; Jim Patterson; David J. Wyper; Donald M. Hadley; G. J. A. Macphee; Donald G. Grosset

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
98 KB
Volume
15
Category
Article
ISSN
0885-3185

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✦ Synopsis

The variability in clinical features and the masking effects of drug therapy in Parkinson's disease (PD) can affect clinical assessment of disease severity. The aim of this study was to assess the imaging of dopamine transporters using 123 I-FP-CIT SPECT and its correlation with disease staging, severity, and duration. Differences between the clinical severity of the onset and non-onset side and the corresponding striatal uptake ratios were also examined. Forty-one patients with PD (nine unilateral, 32 bilateral clinical features) were studied. Clinical severity was determined by using the Unified Parkinson's Disease Rating Score (UPDRS). Unilateral UPDRS was calculated from unilateral arm and leg resting and action tremor, rigidity, finger taps, hand movements, alternating movements, and leg agility. 123 I-FP-CIT striatal uptake was expressed as the ratio of specific:nonspecific (SP:NS) uptake for defined brain areas. Patients with PD who had unilateral symptoms showed a significant difference between the ipsilateral and contralateral SP:NS ratios in both the caudate and

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