✦ LIBER ✦

Correlation of nitrogen-14 nuclear quadrupole resonance data in sulfanilamides with the in vitro activities

✍ Scribed by S. N. Subbarao; P. J. Bray

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 349 KB
Volume: 15
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1270150320

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✦ Synopsis

Abstract

Several sulfanilamide‐type compounds in their solid state have been investigated by the ^14^N nuclear quadrupole resonance (NQR) technique. The electron distributions at the sites of the nitrogen atoms, calculated by the Townes and Dailey theory, indicate a significant correlation between the quadrupole coupling constant for the primary amino nitrogen (N^4^), which is a measure of the (π‐σ) electron density at N^4^, and the in vitro bacteriostatic activity of the sulfanilamides.

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✍ S. G. Greenbaum; S. N. Subbarao; P. J. Bray; T. Oja 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 400 KB

## Abstract ^14^N nuclear quadrupole resonance (NQR) spectra of 22 monosubstituted anilines are reported and analyzed in the framework of the Townes and Dailey theory. Satisfactory correlations of the NQR data with both the Hammett σ parameters and the __in vitro__ biological activities of the corr