Correlation of L-myc RFLP with metastasis, prognosis and multiple cancer in lung-cancer patients

✍ Scribed by Kazuko Kawashima; Sachio Nomura; Hiroyuki Hirai; Shuetsu Fukushi; Tsuyoshi Karube; Kumiko Takeuchi; Tsuguo Naruke; Susumu Nishimura

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: French
• Weight: 457 KB
• Volume: 50
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910500411

✦ Synopsis

For further study of the correlation of L-myc restrictionfragment-length polymorphism (RFLP) and metastasis of lung cancer to lymph nodes or other organs at the time of surgery, L-myc RFLP was analyzed in 252 Japanese lung-cancer patients. A close correlation between L-myc RFLP and metastasis was confirmed in this large number of patients (p = 0.01). The correlation was particularly pronounced in cases of adenocarcinoma and squamous-cell carcinoma. Poor prognosis (additional metastases after surgery) was observed in lung-cancer patients with L-S (identified as long and short bands produced with EcoRI) and S-S type L-myc RFLP. In addition, the death rate of lung-cancer patients with the L-S and S-S types was greater than that of those with the L-L type. Lung-cancer patients of the L-S and S-S types had almost 4 times higher incidence of multiple cancer in the lung, pharynx and other organs than those with the L-L type. Our results indicate that, in patients with lung cancer, genetic disposition with respect to the L-myc gene influences the extent of metastasis, the incidence of multiple cancers and prognosis.