## Abstract ## BACKGROUND Gastrointestinal stromal tumors (GISTs) are noncomplex sarcomas that often are due to __c‐kit__‐activating and platelet‐derived growth factor receptor α gene (__PDGFRα__)‐activating mutations and perturbations of their related signaling pathways. Molecular and cytogenetic
✦ LIBER ✦
Correlation of KIT and platelet-derived growth factor receptor α mutations with gene activation and expression profiles in gastrointestinal stromal tumors
✍ Scribed by Kang, Hyun Ju; Nam, Suk Woo; Kim, Hyunki; Rhee, Hwanseok; Kim, Nam-Gyun; Kim, Haeryoung; Hyung, Woo Jin; Noh, Sung Hoon; Kim, Joo-Hang; Yun, Chae-Ok
- Book ID
- 110069419
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 331 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Most gastrointestinal stromal tumors (GISTs) have gain‐of‐function mutations of the c‐__kit__ gene. Previously, we found 2 types of gain‐of‐function mutation of the __PDGFRA__ gene, Val^561^ to Asp and Asp^842^ to Val, in about half of GISTs without c‐__kit__ gene mutations. Although th