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Correlation of in vivo and in vitro activities of a series of arylmethyl phenyl ethers with 5-lipoxygenase (LOX) inhibitory properties

✍ Scribed by P. Sonnino-Goldman; S. Coutts; D. Donigi Ruzza; S. Hyman; N. Jariwala; J. Bruens; U. Chakraborty; E. Neiss; I. Weinryb


Book ID
103624590
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
96 KB
Volume
7
Category
Article
ISSN
0192-0561

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Leukotrienes are biologically active lipid mediators capable of producing airway inflammation, hyperresponsiveness and bronchoconstriction. The first enzyme in the metabolic pathway of arachidonic acid leading to the leukotrienes is 5-lipoxygenase (5-LO). A selective and potent 5-LO inhibitor, zileu