The 5-Lipoxygenase Inhibitory Activity o
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P.E. Malo; R.L. Bell; T.K. Shaughnessy; J.B. Summers; D.W. Brooks; G.W. Carter
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Article
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1994
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Elsevier
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English
β 417 KB
Leukotrienes are biologically active lipid mediators capable of producing airway inflammation, hyperresponsiveness and bronchoconstriction. The first enzyme in the metabolic pathway of arachidonic acid leading to the leukotrienes is 5-lipoxygenase (5-LO). A selective and potent 5-LO inhibitor, zileu