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Correlation of general anesthetic potency with solubility in membranes

โœ Scribed by Andrew S. Janoff; Michael J. Pringle; Keith W. Miller

Book ID
115724915
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
321 KB
Volume
649
Category
Article
ISSN
0005-2736

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Use of ion-exchange membranes to measure
Use of ion-exchange membranes to measure transfer free energies of charged local anesthetics: Correlation to anesthetic potency
โœ Norihito Kitagawa; Yoshiroh Kaminoh; Mitsuhiro Takasaki; Issaku Ueda ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 476 KB

Ion-selective electrodes, sensitive to local anesthetic cations, were prepared with carboxylated poly(viny1 chloride) (PVC) membranes. Three plasticizers with varying degrees of polarity were used to adjust the hydrophobicity of the membrane. The affinity of the drug to the ion-exchange membrane was