Correlation of ERG and pigment epithelium changes in external progressive ophthalmoplegia (EPO)
✍ Scribed by P. Steindler; A. P. Tormene; G. F. Micaglio; A. Galan
- Publisher
- Springer-Verlag
- Year
- 1985
- Tongue
- English
- Weight
- 869 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0012-4486
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✦ Synopsis
Six out of 17 patients with progressive external oplithalmoplegia (EPO) were found to have pigment anomalies with alterations in the electroretinographical (ERG) tracings. However, fluorangiography demonstrated alterations of the retinal pigment epithelium in patients with normal fundus and ERG examinations. We conclude that in our series there was no correlation between retiuopathy and tapetoretinal degeneration. been involved in various biochenrical disorders (Di Mauro, 1973).
An association between EPO and retinitis pigmentosa was reported by Croft et al. (1977) in about 11% of his cases of EPO; additionally, he found retinitis pigmentosa in 13 cases among the 348 reported in the literature.
The numerous associations found between EPO and other diseases on the one hand attest to the interest in EPO but on the other have prompted authors to describe numerous 'new syndromes'. The descriptions, based on clinical and laboratory findings, make it difficult to work out a nosologic picture of EPO, because conditions reported as new syndromes by some authors are considered new variants by others.
Various classifications have been proposed such as those of Drachman (1968), Glaser (1978), andBastiaensen et al. (1982), the last following on the