๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Correlation of DNA ploidy and clinical outcome in borrmann type 4 gastric carcinoma

โœ Scribed by Dr Yutaka Yonemura; Kazuo Sugiyama; Takashi Fujimura; Toru Kamata; Takeo Kosaka; Sachio Fushida; Akio Yamaguchi; Koichi Miwa; Itsuo Miyazaki

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
384 KB
Volume
42
Category
Article
ISSN
0022-4790

No coin nor oath required. For personal study only.

โœฆ Synopsis

The correlation between DNA ploidy pattern and clinical outcome was studied in 76 patients with Borrmann type 4 gastric carcinomas. Twentysix tumors were diploid, and 50 tumors were aneuploid. There was no correlation among DNA ploidy and histologic type, lymph-node status, wall invasion, or clinical stage. The incidence of vascular invasion in the aneuploid tumors was significantly higher than that in the diploid tumors. Five year survival was achieved in 28% of the patients with diploid tumors and 8% of those with aneuploid tumors, respectively. Among the patients undergoing curative resection, 5 year survival rate was 54% in the patients with diploid tumors compared to 28% with aneuploid tumors. There was a significant survival advantage in patients with diploid tumors. These results indicate that DNA ploidy might be an important prognostic factor in Borrmann type 4 gastric carcinomas.

๐Ÿ“œ SIMILAR VOLUMES

Prognostic factors in retroperitoneal sa
Prognostic factors in retroperitoneal sarcomas: Ploidy of DNA as a predictor of clinical outcome
โœ Herman, Krzysztof; Grucha?a, Andrzej; Niezabitowski, Aleksander; Gli?ski, Bogdan ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 81 KB ๐Ÿ‘ 2 views

## Background and objectives: Radical surgery is the best mode of treatment of retroperitoneal sarcomas (rs); however, common recurrences are unpredictable. ## Methods: For the better understanding of outcomes and possibilities of treatment retrospective analysis of different factors, including d

Intratumor heterogeneity of DNA ploidy a
Intratumor heterogeneity of DNA ploidy and correlations with clinical stage and histologic grade in prostate cancer
โœ Dr. Omer Kucuk; Taner Demirer; Alice Gilman-Sachs; Irene Taw; Michael Mangold; S ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 363 KB

Paraffin blocks from 60 patients with prostate cancer were used to study the DNA ploidy patterns by flow cytometry. Nineteen patients had stage A disease, 11 had stage B, 9 had stage C , 20 had stage D, and 1 was of unknown stage. Histologically, 32 of the cancers were well differentiated, 2 1 were

Prognostic significance of tumor-host in
Prognostic significance of tumor-host interaction in clinical gastric cancer: Relationship between dna ploidy and dendritic cell infiltration
โœ Dr. Yoshihiro Kakeji; Yoshihiko Maehara; Daisuke Korenaga; Shunichi Tsujitani; M ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 467 KB

DNA ploidy of tumor cells and the degree of infiltration of dendritic cells were determined in 93 gastric cancer tissue specimens, and the mechanisms of tumor-host interaction on the prognosis were investigated. DNA ploidy patterns were grouped into low and high ploidy, and the degree of infiltratio

Correlation of DNA ploidy and histologic
Correlation of DNA ploidy and histologic diagnosis from prostate core-needle biopsies: Is DNA ploidy more sensitive than histology for the diagnosis of carcinoma in small specimens?
โœ Lo, Jeanne; Kerns, Billie-Jo; Amling, Christopher L.; Robertson, C. N.; Layfield ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 492 KB ๐Ÿ‘ 2 views

DNA ploidy has been shown to have prognostic value in adenocarcinoma of the prostate. While occasional benign lesions of the prostate may be associated with a DNA aneuploid status, most aneuploid epithelial proliferations of the prostate are carcinomas. Because of the relationship between aneuploidy