Correlation of Coordination Geometries and Stability Factors in Organotin(IV) Derivatives of 4-Acylpyrazol-5-onates with their Fungicidal (Mycelial Control) and Insecticidal (Topical Toxicity, Larvicidal and Ovicidal) Activities
✍ Scribed by B. Ayo Omotowa; M. Adediran Mesubi
- Book ID
- 101280211
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 93 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0268-2605
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✦ Synopsis
The fungicidal and insecticidal activities of the 4-acetyl (HPMAP) and 4-benzoyl (HPMBP) derivatives of 3-methyl-l-phenylpyrazol-5-one and their complexes with diorganotins [Bu 2 Sn(PMAP) 2 , Bu 2 Sn(PMBP) 2 , Ph 2 Sn(PMAP) 2 and Ph 2 Sn(PMBP) 2 ] and triorganotins [Bu 3 SnPMAP, Ph 3 SnPMAP, Bu 3 Sn(PMBP)(H 2 O) and Ph 3 SnPMBP] have been determined and their ED 50 (fungicidal activity) and LC 50 (insecticidal activity) values are reported. An attempt has been made to correlate the type of coordination geometry around the tin atom [based on published 119 Sn NMR and 119 Sn Mössbauer data as well as on the crystal structures of Bu 2 Sn(PMBP) 2 and Bu 3 Sn(PMBP)(H 2 O)] and the relative stabilities with the observed bioactivities in these compounds. The diorganotin complexes are more effective than the triorganotins as insecticides. The effect of disproportionation of R 3 SnL to give R 4 Sn and R 2 SnL 2 is discussed with respect to insecticidal activity. The stability constants of the diorganotin compounds are reported, and they suggest that these compounds are sufficiently stable to prevent appreciable ligand exchange before their assimilation into the living tissues of the insects.