Correlation between various cell-surface antigens induced by murine leukemia virus in the rat: Serological analysis
✍ Scribed by Noboru Kuzumaki; Noritoshi Takeichi; Fujiro Sendo; Takao Kodama; Hiroshi Kobayashi
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- French
- Weight
- 644 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Analysis based on the cytotoxicity test using antisera produced in rats indicated the presence of various cell‐surface antigens on the tumors in WKA/Mk rats induced or artificially infected by Friend, Rauscher or Gross viruses. Each line of the tumor was found to have a common antigen, namely group‐specific cell‐surface antigen. A Gross type‐specific and Friend and Rauscher type‐specific cell‐surface antigens were also detected, in keeping with the observations in the mouse system. In addition, the present experiments strongly suggested that a Friend strain‐specific antigen was detected only on the cell‐surface of the tumors in WKA/Mk rats induced or artificially infected by Friend virus. These results were in parallel with the data of previously reported transplantation studies.