Correlation between umbilical artery and vein levels of interleukin-6 and soluble intracellular adhesion molecule-1

✍ Scribed by John C. Smulian; Winston A. Campbell; Anthony M. Vintzileos; John F. Rodis

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 40 KB
• Volume: 6
• Category: Article
• ISSN: 1057-0802
• DOI: 10.1002/(sici)1520-6661(199703/04)6:2<67::aid-mfm1>3.0.co;2-n

✦ Synopsis

This study was designed to determine whether umbilical artery levels of both interleukin-6 (IL-6) and soluble intracellular adhesion molecule-1 (sICAM-1) correlate with levels in the umbilical vein. Paired umbilical artery-vein specimens were assayed for IL-6 and sICAM-1. The paired-sign test was used to compare umbilical artery vein levels of IL-6 and sICAM-1. Spearman rank correlation was used to determine relationships between paired umbilical artery-vein levels for a variety of clinical subgroups. For 23 paired samples overall, umbilical artery levels were greater than corresponding vein levels for both IL-6 (P 5 .039) and sICAM-1 (P 5 .035). Artery-vein correlations were significant for IL-6 (rho 5 0.845, P 5 .0001) and sICAM-1 (rho 5 0.806, P 5 .0002). Correlations were not influenced by prematurity, route of delivery, labor, or neonatal sepsis. In conclusion, umbilical artery levels of IL-6 and sICAM-1 correlate significantly with umbilical vein levels.