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Correlation between the photostability and photodynamic efficacy for different photosensitizers

โœ Scribed by J. Ferreira; C. Kurachi; L. T. Moriyama; P. F. C. Menezes; J. R. Perussi; C. Sibata; S. Zucoloto; O. Castro e Silva Jr.; V. S. Bagnato

Book ID
102444859
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
135 KB
Volume
3
Category
Article
ISSN
1612-2011

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โœฆ Synopsis

Using three haematoporphyrin based photosensitizers we
investigated their properties related to the phototransformation
in solution, the inhibitory concentration (IC~50~) in cell
culture and the threshold dose (D~th~) in rat livers. The
observation of such properties shows the existence of a strong
correlation among them. The photosensitizer with the highest
phototransformation rate is also the one with the lowest D~th~
and IC~50~, showing more efficacy in cell killing and tissue
necrosis during photodynamic therapy applications. We discuss this
explanation for such correlation and the possible practical
applications for this property.

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The ability of a photosensitizer to partition into membrane is determined by its structure and physical properties. Partitioning behavior can be quantitated as the partition coefficient (K,) for a particular drug. This property may be an important determinant of cytocidal efficacy in photodynamic th