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Correlation between serum antibody-levels against group B streptococci and gestational age in newborns

✍ Scribed by K. K. Christensen; P. Christensen; G. Duc; P. Höger; C. Kind; T. Matsunaga; B. Müller; R. A. Seger

Publisher
Springer
Year
1984
Tongue
English
Weight
256 KB
Volume
142
Category
Article
ISSN
0340-6997

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✦ Synopsis

Sera from 33 newborn infants with gestational ages ranging from 27 to 41 weeks were tested by radioimmunoassay for IgG antibodies to surface antigens of group B streptococci (GBS) types Ia, Ib, II and III. Antibody levels to GBS antigens were positively correlated to gestational age and birthweight. However, only the correlations for antMa and anti-II antibody levels reached statistical significance. Mean antibody concentrations in infants below 34 weeks of gestation were significantly lower for type Ia (P < 0.001), type II (P < 0.001) and type III (P = 0.05) than in infants above this limit. These findings might explain the higher rate of serious GBS-infcctions found among prematures as compared to full-term infants.

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Intravenous administration of human IgG
Intravenous administration of human IgG to newborn infants: changes in serum antibody levels to group B streptococci
✍ K. K. Christensen; P. Christensen; H. U. Bucher; G. Duc; C. H. Kind; D. Mieth; B 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 511 KB

A human IgG preparation was given intravenously to 36 newborn infants admitted to the neonatal intensive care unit because of suspected septicaemia. IgG was given as a single dose of 0.4 g/kg body weight. Patient serum was obtained immediately before and 30 min after terminating the infusion. Blood