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Correlation between low/high affinity ratios for 5-HT1A receptors and intrinsic activity

✍ Scribed by Marie-Bernadette Assié; Cristina Cosi; Wouter Koek

Book ID
114017662
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
139 KB
Volume
386
Category
Article
ISSN
0014-2999

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The ternary complex model as applied to G-protein coupled receptors (GPCR) predicts that an agonist binds with low affinity (K L ) to the free receptor (R), leading to an agonist/receptor/G-protein complex. This ternary complex displays high agonist affinity (K H ), resulting in signal transduction.