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Correlation between lethality and DNA single-strand breaks in Bacillus subtilis cells treated with N-methyl-N′-nitro-N-nitrosoguanidine

✍ Scribed by D.L. Dugle; C.E. Campbell; B.E. Meeker; C.J. Gillespie


Book ID
116036701
Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
472 KB
Volume
18
Category
Article
ISSN
0027-5107

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Kinetics of induction of DNA damage and
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␤-Propiolactone (BPL) and N-methyl-NЈ-nitro-N-nitrosoguanidine (MNNG) are two direct alkylating agents that induce multiple genetic lesions and tumors in the rodent stomach. We measured the kinetics of the induction of DNA damage by using the single-cell gel electrophoresis assay (SCGE) and the indu