Correlation between karyotypic pattern and clinicopathologic features in 125 breast cancer cases

✍ Scribed by Nikos Pandis; Ingrid Idvall; Georgia Bardi; Yuesheng Jin; Ludmila Gorunova; Fredrik Mertens; Håkan Olsson; Christian Ingvar; Konstantine Beroukas; Felix Mitelman; Sverre Heim

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 613 KB
• Volume: 66
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19960410)66:2<191::aid-ijc9>3.0.co;2-y

✦ Synopsis

A correlation analysis was performed on I25 cytogenetically characterized breast cancer cases to assess the relationship between the tumor karyotype and clinicopathologic features. The carcinomas of young women had a higher modal chromosome number than those of older women. The number of chromosomal aberrations and modal chromosome number were also found to correlate with the histologic type, grade and mitotic activity of the tumor. Whereas all lobular carcinomas were karyotypically normal or near-diploid, more than 3 aberrations and sometimes near-triploid or near-tetraploid karyotypes were common findings in ductal carcinomas, especially in grade-Ill tumors and in tumors showing high mitotic activity in vivo. Karyotypes with cytogenetically unrelated clones and unbalanced structural chromosomal rearrangements were more frequent in infiltrating than in in situ carcinomas but, at least as far as the second of these 2 characteristics is concerned,