✦ LIBER ✦

Correlation between insulin resistance and hepatitis C viral load

✍ Scribed by Stephen A. Harrison

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 49 KB
Volume: 43
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.21125

No coin nor oath required. For personal study only.

✦ Synopsis

I read with interest the timely article by Bugianesi et al. detailing insulin resistance in chronic liver disease. As briefly mentioned in this article, chronic hepatitis C (CHC) is associated with insulin resistance (IR) and the co-existence of NAFLD and IR with CHC is associated with decreased sustained virological responses (SVR) to antiviral therapy.

Recently, it has been demonstrated in a hepatitis C replicon system (Apath, Clone B (S11791) that hyperinsulinemia increases HCV-RNA replication. We have evaluated 64 naı ¨ve CHC patients and found that IR correlated with higher viral loads (P ϭ .04). Insulin resistance was determined by the quantitative insulin sensitivity check index (QUICKI). A score of Ͻ0.35 (equivalent to HOMA Ͼ1.8) was used as an indicator of IR:

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