Correlation between inhibitory effect on platelet aggregation and disposition of sulfinpyrazone and its metabolites in rabbits. Part II: Multiple dose study

Correlation between inhibitory effect on

Correlation between inhibitory effect on platelet aggregation and disposition of sulfinpyrazone and its metabolites in rabbits. Part I: Single dose study

✍ Wolfgang A. Ritschel; Be-Sheng Kuo 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 427 KB 👁 2 views

Simultaneous evaluation of inhibition of the sodium arachidonate-induced platelet aggregation and drug disposition was studied in rabbits receiving single doses of sulfinpyrazone (SO) and its sulfide metabolite (S). The metabolism of SO was found to be interconversible with that of S. Due to the par