Correlation between HIV-1 seropositivity and prevalence of a γ-secretase polymorphism in two distinct ethnic populations
✍ Scribed by Karen M.J. van Loo; Jessica E. van Schijndel; Martine van Zweeden; Daniëlle van Manen; Mieke D. Trip; Desiree C. Petersen; Hanneke Schuitemaker; Vanessa M. Hayes; Gerard J.M. Martens
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 77 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Abstract
Susceptibility for human immunodeficiency virus type 1 (HIV‐1) infection may be influenced by host genetics. Recent findings with a Wistar rat model raised the possibility that the γ‐secretase pathway may be associated with an individual's susceptibility to infection. A functional single‐nucleotide polymorphism (SNP) in the γ‐secretase component APH1B (Phe217Leu; rs1047552) was therefore analyzed for association with HIV‐1 infection. The SNP showed a tendency for association with HIV‐1 infection in a Xhosa indigenous South African Bantu study (P = 0.087), and associated significantly in a Caucasian Dutch study (P = 0.049). Together, the results suggest a role for the γ‐secretase pathway in susceptibility to HIV‐1 infection. J. Med. Virol. 81:1847–1851, 2009. © 2009 Wiley‐Liss, Inc.