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Correlation between DNA methylation and expression of O6-methylguanine-DNA methyltransferase gene in cultured human tumor cells

✍ Scribed by Wang, Yi; Kato, Tomohisa; Ayaki, Hitoshi; Ishizaki, Kanji; Tano, Keizo; Mitra, Sankar; Ikenaga, Mituo


Book ID
123385261
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
747 KB
Volume
273
Category
Article
ISSN
0921-8777

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## Abstract __O__^6^‐methylguanine‐DNA methyltransferase (__MGMT__) is a DNA repair gene which is frequently methylated in colorectal cancer (CRC). However, it remains controversial whether methylation of specific CpG sequences within __MGMT__ promoter leads to loss of its protein expression, and i