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Correlation between dissolution characteristics and absorption of methaqualone from solid dosage forms

โœ Scribed by P. B. Chemburkar; R. D. Smyth; J. D. Buehler; P. B. Shah; R. S. Joslin; A. Polk; N. H. Reavey-Cantwell

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
543 KB
Volume
65
Category
Article
ISSN
0022-3549

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Correlation between in vitro dissolution
Correlation between in vitro dissolution profiles from enteric-coated dosage forms and in vivo absorption in rats for high-solubility and high-permeability model drugs
โœ Shinji Sakuma; Ryoko Ogura; Yoshie Masaoka; Makoto Kataoka; Fumiรฉ K. Tanno; Hiro ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 161 KB ๐Ÿ‘ 1 views

We examined the in vitro dissolution-in vivo absorption correlation (IVIVC) for enteric-coated granules containing theophylline, antipyrine or acetaminophen as model drugs with high solubility and high permeability. More than 85% of each drug was released from granules coated with hypromellose aceta