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Correlation between conformational stability of the ternary enzyme–substrate complex and domain closure of 3-phosphoglycerate kinase

✍ Scribed by Andrea Varga; Beáta Flachner; Éva Gráczer; Szabolcs Osváth; Andrea N. Szilágyi; Mária Vas


Book ID
111309938
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
851 KB
Volume
272
Category
Article
ISSN
1432-1327

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A general method of domain closure is ap
✍ Nagasuma R. Chandra; Hilary Muirhead; J. John Holbrook; Bradley E. Bernstein; Wi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 424 KB 👁 1 views

The occurrence of large domain motions associated with the mechanism of action of many proteins is well established. We present a general method of predicting domain closure applicable to proteins containing domains separated by an apparent hinge. The method attempts to allow for natural directional