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Correlation between birth cohort and age at diagnosis of colorectal cancer in HNPCC families

✍ Scribed by D. Assisi; P. Fracasso; V. Stigliano; A. Ricciotti; V. Casale

Book ID: 119629882
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 170 KB
Volume: 32
Category: Article
ISSN: 1590-8658
DOI: 10.1016/s1590-8658(00)80557-5

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## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominantly inherited cancer syndrome associated with germline mutations in DNA mismatch repair (MMR) genes. Recently a polymorphism at codon 72 (R72P) in the tumour suppressor gene __TP53__ has been implicated in the age