Correlation between antiretroviral resistance mutations, biological parameters, and clinical evolution in zidovudine-treated patients infected with human immunodeficiency virus type 1

A microtitre format point mutation assay

A microtitre format point mutation assay: Application to the detection of drug resistance in human immunodeficiency virus type-1 infected patients treated with zidovudine

✍ Steve Kaye; Clive Loveday; Richard S. Tedder 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 496 KB 👁 1 views

## Abstract An assay for the analysis of point mutations in DNA fragments amplified by the polymerase chain reaction is described. The method was applied to the analysis of mutations leading to single amino acid changes in the reverse transcriptase gene of human immunodeficiency virus type‐1 that a