Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis

Chromosomal fragile sites FRA3B and FRA1

Chromosomal fragile sites FRA3B and FRA16D show correlated expression and association with failure of apoptosis in lymphocytes from patients with thyroid cancer

✍ Isabella Sbrana; Franca Veroni; Maria Nieri; Aldamaria Puliti; Roberto Barale 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 163 KB

## Abstract It has been suggested that common fragile sites (cFSs) are related to cancer development. This appears to be the case for FRA3B and FRA16D, localized in two tumor‐suppressor genes (__FHIT__ and __WWOX__, respectively) that are altered by deletions or loss of heterozygosity (LOH) in many