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Correlated expression of a B-lymphocyte-specific glycoprotein (gp27/35) and the EBV receptor/c3 receptor complex in sublines from the same Burkitt lymphoma

✍ Scribed by George Klein; Robert Hyman; Ian Trowbridge

Publisher: John Wiley and Sons
Year: 1979
Tongue: French
Weight: 427 KB
Volume: 23
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910230108

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✦ Synopsis

Abstract

A series of virus‐producer and non‐producer sublines, derived from the Burkitt lymphoma line Jijoye and its P3HR‐1 clone, were previously found to differ in the expression of EBV receptors and, in parallel, C3 receptors. The differences could be related to an “internal selection” caused by the cytopathic P3HR‐1 virus variant, favouring the growth of receptor‐negative cells. We have now analyzed the same lines for the expression of a B‐lymphocyte‐specific glycoprotein (gp27/35). A close parallellism was found between the expression of the EBV receptor‐complement receptor complex and the glycoprotein, measured by quantitative absorption. The results favour a relationship between gp27/35 and EBV/C3 receptor expression.

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✍ George Klein; Eitan Yefeno; Kerstin Falk; Anitha Westman 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 808 KB

## Abstract Virus production, EBV (P3HR‐1 substrain) superinfectability, IdUrd inducibility, EBV receptor and complement (C3) receptor expression were assessed in two independently maintained Jijoye lines, the derived P3HR‐1 clone that releases a growth inhibitory and cytopathic, non‐transforming v