Coronary magnetic resonance angiography: Experimental evaluation of the new rapid clearance blood pool contrast medium P792

✍ Scribed by Matthias Taupitz; Jörg Schnorr; Susanne Wagner; Dietmar Kivelitz; Patrik Rogalla; Gerlind Claaßen; Marc Dewey; Philippe Robert; Claire Corot; Bernd Hamm

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 258 KB
• Volume: 46
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1279

✦ Synopsis

Abstract

The signal‐enhancing characteristics of a new monodisperse monogadolinated macromolecular MR contrast medium (P792) were evaluated for magnetic resonance angiography (MRA) of the coronary arteries. A total of 15 cardiac examinations were performed in pigs at 1.5 T using a 3D gradient‐echo sequence. Images were acquired during breath‐hold before and up to 35 min after IV injection of Gd‐DTPA (0.3 mmol Gd/kg), Gd‐BOPTA (0.2 mmol Gd/kg), and P792 (13 μmol Gd/kg). An increase in the signal‐to‐noise ratio (SNR) of 97% ± 17%, 108% ± 37%, and 109% ± 31% in coronary arteries and of 82% ± 19%, 82% ± 24%, and 28% ± 18% in myocardium, respectively, was measured during the first postcontrast acquisition. The blood‐to‐myocardium signal‐difference‐to‐noise ratio (SDNR) was significantly higher for P792 than for the other Gd compounds (P < .05) for up to 15 min after injection. Qualitative assessment showed that visualization of the coronary arteries and their branches was significantly better for P792 compared to the low‐molecular Gd compounds (P < .05). The blood pool contrast medium P792 is well suited for MRA of the coronary arteries. Magn Reson Med 46:932–938, 2001. © 2001 Wiley‐Liss, Inc.