Coronary artery lumen volume measurement using three-dimensional intravascular ultrasound: Validation of a new technique
✍ Scribed by Matar, Fadi A. ;Mintz, Gary S. ;Douek, Philippe ;Farb, Andrew ;Virmani, Renu ;Javier, Saturnine P. ;Popma, Jeffrey J. ;Pichard, Augusto D. ;Kent, Kenneth M. ;Satler, Lowell F. ;Keller, Michael ;Leon, Martin B.
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 622 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0098-6569
No coin nor oath required. For personal study only.
✦ Synopsis
Objective: To validate an automated algorithm for the measurement of lumen volumes of coronary arteries. Background: Current intravascular ultrasound systems use absolute measurements of and changes in areas and diameters for the assessment of coronary artery disease. However, the coronary artery is a three-dimensional structure of complex geometry and volume. Methods: We used a comprehensive imaging system designed to reconstruct planar intravascular ultrasound images in three dimensions. This system consisted of a 25 MHz transducer-tipped rigid probe (for in vitro studies) or a 25 MHz transducer-tipped catheter within a 3.9F monorail imaging sheath (for in vivo studies), a motorized catheter pullback device that withdrew the transducer at 0.5 mm/sec, and an image processing computer that stacked 15 image slices/mm of vessel axial length and then performed thresholding-based three-dimensional image rendering and lumen volume measurement. We imaged 13 human coronary vessels (6 RCA, 6 LAD, 1 LCX) in vitro and 16 vessels (8 LAD, 6 RCA, 2 SVG) in vivo. Results: In vitro studies: Lumen volumes derived by three-dimensional intravascular ultrasound were 171 f 121 mm3 and compared very well with those derived by histology (160 f 109 mm3, r = 0.97, SEE = 29 mm3, P < 0.001) and with those derived by manual planimetry of planar intravascular ultrasound images (150 f 106 mm3, r = 0.97, SEE = 30 mm3, P < 0.001). In vivo studies:
Lumen volumes derived by three-dimensional intravascular ultrasound were 74 f 35 mm3 and compared well with those derived by quantitative angiography (52 f 20 mm3, r = 0.71, SEE = 25 mm3, P < 0.002). Conclusions: Three-dimensional intravascular ultrasound is a new technique that can accurately measure coronary artery lumen volumes. Further technical improvements may help to establish this technique as the new standard for lumen volume measurement. o 1994 Wiley-Liss, Inc.