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Corey–Itsuno Reduction of Ketones: A Development of Safe and Inexpensive Process for Synthesis of Some API Intermediates

✍ Scribed by Mahale, Rajendra D.; Chaskar, Sudhir P.; Patil, Kiran E.; Maikap, Golak C.; Gurjar, Mukund K.


Book ID
111985301
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
307 KB
Volume
16
Category
Article
ISSN
1083-6160

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We report here a novel procedure for the reduction of ketones to secondary alcohols using catalytic quantities of commercially available Cp 2 TiCl 2 , inexpensive Zn dust and water as proton source. Mechanistically the reaction presumably proceeds via titanoxy radicals. In practice this reduction pr