𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Core promoter mutations (A1762T and G1764A) and viral genotype in chronic hepatitis B and hepatocellular carcinoma in Guangxi, China

✍ Scribed by Zhong-Liao Fang; Jinye Yang; Xianmin Ge; Hui Zhuang; Jian Gong; Rongcheng Li; Roger Ling; Tim J. Harrison

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
148 KB
Volume
68
Category
Article
ISSN
0146-6615

No coin nor oath required. For personal study only.

✦ Synopsis

Hepatitis B viruses (HBV) with core promoter mutations (A(1762)T, G(1764)A) were found in a previous study to be highly prevalent in patients from Guangxi, China with hepatocellular carcinoma (HCC). The aim of this study was to determine whether the mutations are prevalent in areas of Guangxi with high and lower incidences of HCC and whether they are associated with other severe sequelae of chronic hepatitis B, including the development of cirrhosis. In addition, the genotypes of the various HBV sequences were determined. Core promoter mutations were significantly more common in HCC patients than asymptomatic carriers from both regions of Guangxi and also were common in patients with cirrhosis and chronic hepatitis. The data also support the hypothesis that genotype C HBV causes more severe liver disease than does genotype B.

πŸ“œ SIMILAR VOLUMES

HBV core promoter mutations prevail in p
HBV core promoter mutations prevail in patients with hepatocellular carcinoma from Guangxi, China
✍ Fang, Zhong-Liao; Ling, Roger; Wang, Shu Sheng; Nong, Jiang; Huang, Chun Song; H πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 160 KB

The development of primary liver cancer frequently is associated with persistent HBV infection, and tumours may arise in individuals who are anti-HBe positive. However, it is unlear whether viruses with an HBeAg-negative phenotype are associated with tumour development or are selected, during seroco

Hepatitis B virus genotype B with G1896A
Hepatitis B virus genotype B with G1896A and A1762T/G1764A mutations is associated with hepatitis B related acute-on-chronic liver failure
✍ Lei Xiao; Bin Zhou; Hongbo Gao; Shiwu Ma; Guifeng Yang; Min Xu; William G.H. Abb πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 209 KB

## Abstract The existence of statistical associations between hepatitis B‐related acute‐on‐chronic liver failure and both hepatitis B virus (HBV) genotype and mutations in the basal core promoter (BCP) and precore (PC) regions needs to be confirmed. A total of 322 patients with a chronic HBV infect

A matched case–control study of hepatiti
A matched case–control study of hepatitis B virus mutations in the preS and core promoter regions associated independently with hepatocellular carcinoma
✍ Shijian Liu; Jiaxin Xie; Jianhua Yin; Hongwei Zhang; Qi Zhang; Rui Pu; Chengzhon πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 99 KB πŸ‘ 1 views

## Abstract This study aimed to determine hepatitis B virus (HBV) mutations associated independently with the risk of hepatocellular carcinoma (HCC), as adjusted with other mutations in the preS and core promoter regions of HBV genotypes B and C. One hundred and forty HBV‐infected patients with HCC

Precore/core promoter mutations and geno
Precore/core promoter mutations and genotypes of hepatitis B virus in chronic hepatitis B patients with fulminant or subfulminant hepatitis
✍ Chun-Jen Liu; Jia-Horng Kao; Ming-Yang Lai; Pei-Jer Chen; Ding-Shinn Chen πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 77 KB πŸ‘ 2 views

## Abstract The association of precore stop codon mutation (A1896), dinucleotide mutation (T1762/A1764) in the basic core promoter of hepatitis B virus (HBV) genome, and genotype of HBV with fulminant or subfulminant hepatitis remains controversial. We studied HBV genotypes as well as mutations in