Core-binding factor α1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5
✍ Scribed by R Nishimura; K Hata; S.E Harris; F Ikeda; T Yoneda
- Book ID
- 117807702
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 462 KB
- Volume
- 31
- Category
- Article
- ISSN
- 8756-3282
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## Abstract The __in vivo__ osteoinductive capacity of porous calcium phosphate ceramics (Ca/P ceramics) with special structure and phase composition had been found for almost decades. The mechanism of the osteoinductivity of porous calcium phosphate is studied by C2C12 cells culture in this paper.
The bone morphogenetic protein (BMP)-2 is a potent osteoinductive signal, inducing bone formation in vivo and osteoblast differentiation from non-osseous cells in vitro. The runt domain-related protein Cbfa1/PEBP2␣A/ AML-3 is a critical component of bone formation in vivo and transcriptional regulat