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Corchorusides A and B, new flavonol glycosides as α-glucosidase inhibitors from the leaves of Corchorus olitorius

✍ Scribed by Preecha Phuwapraisirisan; Thanchanok Puksasook; Udom Kokpol; Khanit Suwanborirux

Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 340 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.08.014

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✦ Synopsis

Corchorus olitorius, a highly fibrous vegetable commonly known as moroheiya, has long been recognized for its hypoglycemic activity. Bioassay-guided fractionation of the leaf extract led to the isolation of two new flavonol glycosides named corchorusides A and B, in addition to a major component, capsugenin-25,30-Ob-diglucopyranoside. Corchoruside A comprises a kaempferol moiety connected with caffeic acid, glucose, and a rare methyl glucuronate (MeGlcA). The occurrence of a caffeoyl moiety in corchoruside A enhanced significantly its inhibitory effect toward a-glucosidase compared to that in corchoruside B.

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