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Copy number variations and loss of heterozygosity identified in myelodysplastic syndrome

โœ Scribed by X. Hu; A. Iqbal; A. Ahmed; G. Raca; X. Xu; D.J. Wolff; R. Burack; D. Mulford; M.M. Li


Book ID
116332615
Publisher
Elsevier
Year
2011
Tongue
English
Weight
31 KB
Volume
204
Category
Article
ISSN
2210-7762

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## Abstract Detailed analysis of mechanisms of genetic loss for specific tumor suppressor genes (TSGs; e.g., __RB1, APC__ and __NF1__) indicates that TSG inactivation can occur by allelic loss of heterozygosity (LOH), without any alteration in DNA copy number. However, the role and prevalence of su