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Copy number polymorphism at chromosome 19 locus associated with late-onset Alzheimer's disease

✍ Scribed by Gary W. Beecham Jr; Nathalie Schnetz-Boutaud; Jackie Bartlett; Adam Naj; John Gilbert; Eden R. Martin; Joseph Buxbaum; Jonathan L. Haines; Margaret A. Pericak-Vance

Book ID
118466133
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
47 KB
Volume
6
Category
Article
ISSN
1552-5260

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## Abstract The __MAPT__ gene that encodes Tau is located on chromosome 17q21, in a region, which has evolved to form two major haplotypes, H1 and H2. There is strong evidence that the H1 haplotype, and a sub‐haplotype (H1C), are overrepresented and associated with increased risk for the sporadic t