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Copy number estimation algorithms and fluorescence in situ hybridization to describe copy number alterations in human tumors

✍ Scribed by Masaya Suzuki; Kiyoko Nagura; Hisaki Igarashi; Hong Tao; Yutaka Midorikawa; Yasuhiko Kitayama; Haruhiko Sugimura


Book ID
115176042
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
332 KB
Volume
59
Category
Article
ISSN
1320-5463

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✍ James H. Barks; Floyd H. Thompson; Raymond Taetle; Jin-Ming Yang; John F. Stone; πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 150 KB πŸ‘ 1 views

DNA amplification is an important mechanism of tumor progression that allows cancer cells to up-regulate the expression of critical genes such as oncogenes and genes conferring drug resistance. Recent studies using comparative genomic hybridization (CGH) revealed increased DNA copies of 20q sequence