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Copper, zinc superoxide dismutase enhances DNA damage and mutagenicity induced by cysteine/iron

โœ Scribed by Seon Joo Yoon; Young Ho Koh; Robert A. Floyd; Jeen-Woo Park

Book ID
114070175
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
124 KB
Volume
448
Category
Article
ISSN
0027-5107

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DNA and RNA strand scission by copper, z
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โœ W. Karol Dowjat; Malkhaz Kharatishvili; Max Costa ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Springer Netherlands ๐ŸŒ English โš– 626 KB

Copper/zinc (Cu/ZnSOD) and manganese (MnSOD) superoxide dismutases which catalyze the dismutation of toxic superoxide anion, O(2-)-, to O2 and H2O2, play a major role in protecting cells from toxicity of oxidative stress. However, cells overexpressing either form of the enzyme show signs of toxicity