✦ LIBER ✦

Copper transport and metabolism: An update

✍ Scribed by Edward D. Harris

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 129 KB
Volume: 11
Category: Article
ISSN: 0896-548X
DOI: 10.1002/(sici)1520-670x(1998)11:2/3<163::aid-jtra8>3.0.co;2-9

No coin nor oath required. For personal study only.

✦ Synopsis

Molecular understandings of copper transport and metabolism have advanced significantly in the past 10 years. In this review we examine two areas where the new information has been particularly rapid and the insights more profound: membrane copper transport and the ferroxidase function of ceruloplasmin. The first is highlighted by discoveries of the genes for Menkes and Wilson's diseases and the realization that both disease genes encode membrane-bound P-type ATPases. The second is a strong confirmation through genetic and clinical evidence that ceruloplasmin has an obligatory function in iron metabolism.

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