Copper-mediated reaction of 2-halopyridines with ethyl bromodifluoroacetate

✍ Scribed by Michael S. Ashwood; Ian F. Cottrell; Cameron J. Cowden; Debra J. Wallace; Antony J. Davies; Derek J. Kennedy; Ulf H. Dolling

• Book ID: 104252433
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 214 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02276-1

✦ Synopsis

A facile process for the preparation of substituted ethyl 2%-pyridyldifluoroacetates 3 is described starting from readily available ethyl bromodifluoroacetate 2 and substituted 2-bromo or 2-chloropyridines 1. This process features a copper-mediated cross-coupling reaction in DMSO and is the first to utilise pyridylbromides or chlorides with ethyl bromodifluoroacetate 2 in this reaction.