✦ LIBER ✦
Copper Complexes as Functional Models for Dopamine β-Hydroxylase – Mechanistic Study of Oxygen Atom Transfer from Cu/O Species to Benzylic C−H Bonds
✍ Scribed by Ingrid Blain; Michel Giorgi; Innocenzo De Riggi; Marius Réglier
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 460 KB
- Volume
- 2001
- Category
- Article
- ISSN
- 1434-1948
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✦ Synopsis
The mechanism of the oxygen atom transfer reaction mediated by copper-oxygen species has been studied through a substrate-binding ligand approach. Oxidations of copper 5-X-IndPY2 type complexes in which an electron donating (X = OMe) or withdrawing group (X = CN) substitutes the aromatic nucleus in position 5, lead to compounds 2b,c and 3b,c resulting from benzylic hydroxylations. With these complexes, where one of the benzylic positions is influenced by [ ‡] Aminoindanes in Oxygen Transfer Reactions, 3. Ϫ Part 2: ref. [8] ; part 1: ref. [9] [a] Chimie,