Copper-catalyzed tandem N-arylation/condensation: synthesis of quinazolin-4(3H)-ones from 2-halobenzonitriles and amides
β Scribed by Chai, Hongxin; Li, Jiarong; Yang, Liupan; Lu, Hongyan; Qi, Zhang; Shi, Daxin
- Book ID
- 126860645
- Publisher
- The Royal Society of Chemistry
- Year
- 2014
- Tongue
- English
- Weight
- 875 KB
- Volume
- 4
- Category
- Article
- ISSN
- 2046-2069
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A series of 2,3-dihydroquinazolin-4(1H)-ones and quinazolin-4(3H)-ones have been synthesized in good to excellent yields and high selectivity by one-pot reaction using isatoic anhydride, ammonium acetate (or amines), and aldehydes in ethanol or in DMSO under mild conditions, respectively. The reacti
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