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Copper-Catalyzed Preparation of γ-Alkylidenebutenolides and Isocoumarins under Mild Palladium-Free Conditions

✍ Scribed by Samuel Inack-Ngi; Raphaël Rahmani; Laurent Commeiras; Gaëlle Chouraqui; Jérôme Thibonnet; Alain Duchêne; Mohamed Abarbri; Jean-Luc Parrain

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
243 KB
Volume
351
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

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A general and efficient copper(I)‐catalyzed cross‐coupling and heterocyclization reaction of terminal alkynes and β‐iodo‐α,β‐unsaturated acid derivatives has been developed under very mild conditions. This method provides easy access from good to excellent yields of a variety of 5‐ylidenebutenolides and 3‐substituted isocoumarins with excellent regio‐ and stereoselectivity. This procedure does not require the use of any expensive supplementary additives, and is palladium‐free.

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ChemInform Abstract: Copper-Catalyzed Pr
ChemInform Abstract: Copper-Catalyzed Preparation of γ-Alkylidenebutenolides and Isocoumarins under Mild Palladium-Free Conditions.
✍ Samuel Inack-Ngi; Raphael Rahmani; Laurent Commeiras; Gaelle Chouraqui; Jerome T 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 37 KB 👁 1 views

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