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Copper-Catalyzed Enantioselective Hydrosilylation of Ketones by Using Monodentate Binaphthophosphepine Ligands

✍ Scribed by Kathrin Junge; Bianca Wendt; Daniele Addis; Shaolin Zhou; Shoubhik Das; Matthias Beller


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
338 KB
Volume
16
Category
Article
ISSN
0947-6539

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## Abstract 17 monodentate phosphepine ligands with a 4,5‐dihydro‐3__H__‐dinaphtho[2,1‐__c__;1β€²,2′‐__e__]phosphepine structural motif have been synthesized and tested in the asymmetric hydrogenation of various β‐keto esters. By variation of the substituents of the aryl group on the phosphorus atom

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## Abstract magnified image Chiral macrocyclic tetra‐ and hexamine macrocycles derived from __trans__‐1,2‐diaminocyclohexane (DACH) in complexes with diethylzinc efficiently catalyze the asymmetric hydrosilylation of aryl alkyl ketones with enantiomeric excess of the product up to 89%. The cyclic