Copper-catalyzed enantioselective conjugate addition of triethylaluminum to 2-cyclopentenone

✍ Scribed by Liming Su; Xingshu Li; Wing Lai Chan; Xian Jia; Albert S.C. Chan

• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 150 KB
• Volume: 14
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(03)00349-5

✦ Synopsis

Bidentate phosphites were prepared starting from BINOL, H 8 -BINOL or 3,3%, 5,5%-tetra-tert-butyl-2,2%-biphenol. Utilization of these ligands in the copper-catalyzed enantioselective conjugate addition of triethylaluminum to 2-cyclopentenone afforded 3-ethylcyclopentanone in up to 94.0% ee.