Copper-catalyzed amidations of bromo sub
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Kenneth R Crawford; Albert Padwa
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Article
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2002
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Elsevier Science
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French
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The C N cross-coupling reaction between aromatic halides and amides has now been applied to 2-and 3-substituted bromofurans and bromothiophenes. Catalytic CuI in the presence of N,N%-dimethylethylenediamine as a ligand and K 3 PO 4 or K 2 CO 3 as the base furnished 2-and 3-substituted amidofurans an